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Article

Expression of mRNA for type IV collagen alpha1, alpha5 and alpha6 chains by cultured dermal fibroblasts from patients with X-linked Alport syndrome.

Matrix biology : journal of the International Society for Matrix Biology - 1 Aug 1998

Sasaki S, Zhou B, Fan W W, Kim Y, Barker D F, Denison J C, Atkin C L, Gregory M C, Zhou J, Segal Y, Sado Y, Ninomiya Y, Michael A F, Kashtan C E

Abstract excerpt

COL4A5 mutations causing X-linked Alport syndrome (XLAS) are frequently associated with absence of the alpha3, alpha4,alpha5 and alpha6 chains of type IV collagen from basement membranes and increased amounts of the alpha1(IV) and alpha2(IV) chains in glomerular basement membrane. Although many C...

Topics

Adolescent
Adult
Cells, Cultured
Collagen
Fibroblasts
Humans
Middle Aged
Mutation
Nephritis, Hereditary
RNA, Messenger
Skin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9749944
DOI: 10.1016/s0945-053x(98)90081-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9749944-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Expression of mRNA for type IV collagen alpha1, alpha5 and alpha6 chains by cultured dermal fibroblasts from patients with X-linked Alport syndrome.PMID 9749944Read ↗

Glomerular expression of type IV collagen chains in normal and X-linked Alport syndrome kidneys.Semantic proximity Read ↗

Deletions in the COL4A5 collagen gene in X-linked Alport syndrome. Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression.Semantic proximity Read ↗

Organization and expression of basement membrane collagen IV genes and their roles in human disorders.Semantic proximity Read ↗

MLPA and cDNA analysis improves COL4A5 mutation detection in X-linked Alport syndrome.Semantic proximity Read ↗

Correlation between mRNA expression level of the mutant COL4A5 gene and phenotypes of XLAS females.Semantic proximity Read ↗

Comparison of alpha5(IV) collagen chain expression in skin with disease severity in women with X-linked Alport syndrome.Semantic proximity Read ↗

Splicing mutations in the COL4A5 gene in Alport's syndrome: different mRNA expression between leukocytes and fibroblasts.Semantic proximity Read ↗

Aberrant splicing of the COL4A5 gene in patients with Alport syndrome.Semantic proximity Read ↗

Comparative distribution of the alpha 1(IV), alpha 5(IV), and alpha 6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients.Semantic proximity Read ↗

The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters.Semantic proximity Read ↗

Coordinate gene expression of the alpha3, alpha4, and alpha5 chains of collagen type IV. Evidence from a canine model of X-linked nephritis with a COL4A5 gene mutation.Semantic proximity Read ↗

Structure of the human type IV collagen COL4A5 gene.Semantic proximity Read ↗

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