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Article

Disruption of nuclear lamin organization blocks the elongation phase of DNA replication.

The Journal of cell biology - 12 Jun 2000

Moir R D, Spann T P, Herrmann H, Goldman R D

Abstract excerpt

The role of nuclear lamins in DNA replication is unclear. To address this, nuclei were assembled in Xenopus extracts containing AraC, a reversible inhibitor that blocks near the onset of the elongation phase of replication. Dominant-negative lamin mutants lacking their NH(2)-terminal domains were added to assembled nuclei to disrupt lamin organization. This prevented the resumption of DNA replication after the...

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Identifiers

PMID: 10851016
DOI: 10.1083/jcb.149.6.1179
PMCID: PMC2175110

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