Herpes Simplex Virus 1 <i> U _L </i> <i>31</i> and <i> U _L </i> <i>34</i> Gene Products Promote the Late Maturation of Viral Replication Compartments to the Nuclear Periphery

Abstract excerpt

Herpes simplex virus 1 (HSV-1) forms replication compartments (RCs), domains in which viral DNA replication, late-gene transcription, and encapsidation take place, in the host cell nucleus. The formation of these domains leads to compression and marginalization of host cell chromatin, which forms a dense layer surrounding the viral RCs and constitutes a potential barrier to viral nuclear egress or primary...

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