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Article

Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome.

Molecular and cellular biology - 1 Jul 2000

Tongaonkar P, Chen L, Lambertson D, Ko B, Madura K

Abstract excerpt

The targeting of proteolytic substrates is accomplished by a family of ubiquitin-conjugating (E2) enzymes and a diverse set of substrate recognition (E3) factors. The ligation of a multiubiquitin chain to a substrate can promote its degradation by the proteasome. However, the mechanism that facilitates the translocation of a substrate to the proteasome in vivo is poorly understood. We have discovered that E2...

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Identifiers

PMID: 10848595
DOI: 10.1128/MCB.20.13.4691-4698.2000
PMCID: PMC85887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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