Article
Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold.
Acta crystallographica. Section D, Biological crystallography - 1 Sept 2005
Krätzner Ralph, Debreczeni Judit E, Pape Thomas, Schneider Thomas R, Wentzel Alexander, Kolmar Harald, Sheldrick George M, Uson Isabel
Abstract excerpt
The Ecballium elaterium trypsin inhibitor II (EETI-II) belongs to the family of squash inhibitors and is one of the strongest inhibitors known for trypsin. The eight independent molecules of EETI-II in the crystal structure reported here provide a good opportunity to test the hypothesis that this small cystine-knot protein (knottin) is sufficiently rigid to be used as a molecular scaffold for protein-engineering...
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