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Article

The alpha2 and alpha5 integrin genes: identification of transcription factors that regulate promoter activity in epidermal keratinocytes.

FEBS letters - 2 Jun 2000

Corbi A L, Jensen U B, Watt F M

Abstract excerpt

We analysed the activity of the proximal promoters of the alpha2 and alpha5 integrin genes in human keratinocytes. An AP-1 site, found in the alpha5 but not the alpha2 promoter, bound c-Jun/c-Fos dimers and contributed strongly to promoter activity. Both promoters had a CCAAT/enhancer binding protein (C/EBP) binding site: the alpha5 C/EBP element enhanced activity, while the alpha2 site was a negative regulatory...

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Share to CCAAT-Enhancer-Binding Proteins
Share to Integrin alpha2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Proto-Oncogene Proteins c-fos

Share to Proto-Oncogene Proteins c-jun

Share to Response Elements

Share to Sp1 Transcription Factor

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 10838085
DOI: 10.1016/s0014-5793(00)01591-x

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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