Article
Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. Fundamental role of an AP-1 element.
The Journal of biological chemistry - 12 Aug 1994
Casatorres J, Navarro J M, Blessing M, Jorcano J L
Abstract excerpt
The keratin 5 gene presents a complex regulation, since it is expressed at different rates in the basal cells of most, if not all, stratified epithelia. We have analyzed the 5'-upstream region of the bovine keratin 5 (BK5) gene and found that the 5.2 kilobases preceding the gene mimic in vitro th...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Binding Sites
- Cattle
- Enhancer Elements, Genetic
- Gene Expression Regulation
- HeLa Cells
- Humans
- Keratinocytes
- Keratins
- Mice
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Oligodeoxyribonucleotides
- Proto-Oncogene Proteins c-jun
- Sequence Homology, Nucleic Acid