Article
Evidence for superantigen involvement in preeclampsia.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Apr 2000
Luppi P, McKnight C, Mathie T, Faas S, Rudert W A, Stewart-Akers A M, Trucco M, DeLoia J A
Abstract excerpt
PROBLEM: Preeclampsia is the leading cause of maternal morbidity and premature fetal delivery in the United States, most likely involving the immune system in disease genesis. In this report, we tested the hypothesis that a superantigen phenomenon is an important factor in the pathogenesis of the disease. METHOD OF STUDY: A semi-quantitative polymerase chain reaction (PCR) was used to assess T-cell receptor (TCR)...
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