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Article

Genetic and Molecular Abnormalities in Tumors of the Bone and Soft Tissues

1 May 2001

Abstract excerpt

BACKGROUND: Malignant transformation requires the accumulation of multiple genetic alterations such as chromosomal abnormalities, oncogene activation, loss of tumor suppressor genes, or abnormalities in genes that control DNA repair and genomic instability. Sarcomas are a heterogeneous group of malignant mesenchymal tumors of difficult histologic classification and strong genetic predisposition. This article...

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Identifiers

PMID: 11378650
DOI: 10.1177/107327480100800304

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