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Article

Origins and divergence times of mammalian class II MHC gene clusters.

The Journal of heredity - 1 Jan 2000

Takahashi K, Rooney A P, Nei M

Abstract excerpt

The class I and II major histocompatibility complex (MHC) genes are apparently subject to evolution by a birth-and-death process. The rate of gene turnover is much slower in the latter genes than in the former. In placental mammals, the class II region can be subdivided into different orthologous subregions or gene clusters (DR, DQ, DO, and DN), but the origins and evolutionary relationships of these gene...

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Identifiers

PMID: 10833044
DOI: 10.1093/jhered/91.3.198

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