Article
Gene-specific differences in the circadian variation of ventricular repolarization in the long QT syndrome: a key to sudden death during sleep?
Italian heart journal : official journal of the Italian Federation of Cardiology - 1 May 2000
Stramba-Badiale M, Priori S G, Napolitano C, Locati E H, Viñolas X, Haverkamp W, Schulze-Bahr E, Goulene K, Schwartz P J
Abstract excerpt
BACKGROUND: In the long QT syndrome (LQTS) most life-threatening cardiac events occur in association with physical or emotional stress. However, a minority of patients dies suddenly during sleep; intriguingly, these sleep-related sudden deaths tend to cluster in families. The mechanism(s) underlying this phenomenon and the reason why it occurs in few selected families are unknown. Recently, some of the LQTS genes...
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