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Article

Differential regulation of exonic regulatory elements for muscle-specific alternative splicing during myogenesis and cardiogenesis.

The Journal of biological chemistry - 26 May 2000

Ichida M, Hakamata Y, Hayakawa M, Ueno E, Ikeda U, Shimada K, Hamamoto T, Kagawa Y, Endo H

Abstract excerpt

Muscle-specific isoform of the mitochondrial ATP synthase gamma subunit (F(1)gamma) was generated by alternative splicing, and exon 9 of the gene was found to be lacking particularly in skeletal muscle and heart tissue. Recently, we reported that alternative splicing of exon 9 was induced by low serum or acidic media in mouse myoblasts, and that this splicing required de novo protein synthesis of a negative...

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PMID: 10821853
DOI: 10.1074/jbc.275.21.15992

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