Article
Alternative splicing of a human alpha-tropomyosin muscle-specific exon: identification of determining sequences.
Molecular and cellular biology - 1 Sept 1992
Graham I R, Hamshere M, Eperon I C
Abstract excerpt
The human alpha-tropomyosin gene hTMnm has two mutually exclusive versions of exon 5 (NM and SK), one of which is expressed specifically in skeletal muscle (exon SK). A minigene construct expresses only the nonmuscle (NM) isoform when transfected into COS-1 cells and both forms when transfected i...
Topics
- Base Sequence
- Cell Line
- DNA
- Exons
- Gene Expression Regulation
- Humans
- Molecular Sequence Data
- Muscles
- Mutation
- RNA Splicing
- Transcription, Genetic
- Tropomyosin