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Article

High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.

Science (New York, N.Y.) - 19 May 2000

Oliver A, Cantón R, Campo P, Baquero F, Blázquez J

Abstract excerpt

The lungs of cystic fibrosis (CF) patients are chronically infected for years by one or a few lineages of Pseudomonas aeruginosa. These bacterial populations adapt to the highly compartmentalized and anatomically deteriorating lung environment of CF patients, as well as to the challenges of the immune defenses and antibiotic therapy. These selective conditions are precisely those that recent theoretical studies...

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Identifiers

PMID: 10818002
DOI: 10.1126/science.288.5469.1251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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