Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast.

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Article

Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast.

Genes & development - 15 May 2000

Mattison C P, Ota I M

Abstract excerpt

The MAP kinase Hog1 transiently accumulates in the nucleus upon activation. Although Hog1 nuclear export correlates with its dephosphorylation, we find that dephosphorylation is not necessary for export. Unexpectedly, a strain lacking the nuclear protein tyrosine phosphatase, Ptp2, showed decreas...

Topics

Adaptation, Physiological
Biological Transport
Cell Nucleus
Cytoplasm
Enzyme Activation
Fungal Proteins
Intracellular Signaling Peptides and Proteins
Microscopy, Fluorescence
Mitogen-Activated Protein Kinases
Mutation
Osmolar Concentration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Phosphothreonine

Phosphotyrosine

Precipitin Tests

Protein Binding

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Protein Tyrosine Phosphatase, Non-Receptor Type 6

Source

Open in PubMed Open full text

Identifiers

PMID: 10817757
PMCID: PMC316617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-10817757-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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