Article
Cancer of the ampulla of Vater: chromosome 17p allelic loss is associated with poor prognosis.
Gut - 1 Jun 2000
Scarpa A, Di Pace C, Talamini G, Falconi M, Lemoine N R, Iacono C, Achille A, Baron A, Zamboni G
Abstract excerpt
BACKGROUND: Cancer of the ampulla of Vater kills 60% of affected patients. Local spread of the tumour (T stage) is the only reliable prognostic factor. Nevertheless, any cancer stage includes long term survivors and patients dying from the disease. The molecular anomalies involved in this process have the potential to serve as additional prognostic markers. AIM: To evaluate if allelic losses (LOH) of chromosomes...
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