Article
Molecular analysis of alpha-thalassemia in Nepal: correlation with malaria endemicity.
Journal of human genetics - 1 Jan 2000
Sakai Y, Kobayashi S, Shibata H, Furuumi H, Endo T, Fucharoen S, Hamano S, Acharya G P, Kawasaki T, Fukumaki Y
Abstract excerpt
Thalassemia is a prevalent hereditary disorder characterized by impaired synthesis of globin chains. It has been suggested that the high frequency of thalassemia might reflect heterozygote advantage due to reduced susceptibility to malaria. In Nepal, malaria has often occurred in places below the altitude of 1,200m. We carried out a microepidemiological study on thalassemia in two neighboring populations in...
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