Multiple recombination events are responsible for the heterogeneity of alpha(+)-thalassemia haplotypes among the forest tribes of Andhra Pradesh, India.

doi:10.1111/j.1469-1809.1991.tb00397.x

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Article

Multiple recombination events are responsible for the heterogeneity of alpha(+)-thalassemia haplotypes among the forest tribes of Andhra Pradesh, India.

Annals of human genetics - 1 Jan 1991

Fodde R, Harteveld C L, Losekoot M, Giordano P C, Khan P M, Nayudu N V, Bernini L F

Abstract excerpt

The presence of several polymorphic markers along the alpha-globin gene complex allows the identification of haplotypes associated with alpha-thalassemia determinants. These are found at very high frequencies in geographic areas where malaria is or has been endemic which suggests a positive selec...

Topics

Alleles
Chromosomes, Human, Pair 16
Gene Frequency
Globins
Haplotypes
Humans
India
Malaria
Recombination, Genetic
Thalassemia

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