Article
Multiple recombination events are responsible for the heterogeneity of alpha(+)-thalassemia haplotypes among the forest tribes of Andhra Pradesh, India.
Annals of human genetics - 1 Jan 1991
Fodde R, Harteveld C L, Losekoot M, Giordano P C, Khan P M, Nayudu N V, Bernini L F
Abstract excerpt
The presence of several polymorphic markers along the alpha-globin gene complex allows the identification of haplotypes associated with alpha-thalassemia determinants. These are found at very high frequencies in geographic areas where malaria is or has been endemic which suggests a positive selective role by the parasitic disease in favour of alpha(+)-thalassemia mutants. A population survey among forest tribal...
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