Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protection against malaria morbidity: near-fixation of the alpha-thalassemia gene in a Nepalese population.

American journal of human genetics - 1 Feb 1991

Modiano G, Morpurgo G, Terrenato L, Novelletto A, Di Rienzo A, Colombo B, Purpura M, Mariani M, Santachiara-Benerecetti S, Brega A

Abstract excerpt

We have previously reported that the Tharu people of the Terai region in southern Nepal have an incidence of malaria about sevenfold lower than that of synpatric non-Tharu people. In order to find out whether this marked resistance against malaria has a genetic basis, we have now determined in these populations the prevalence of candidate protective genes and have performed in-vitro cultures of Plasmodium...

Topics

Animals
Blotting, Southern
DNA
Electrophoresis, Cellulose Acetate
Erythrocytes
Genetic Markers
Heterozygote
Homozygote
Malaria
Nepal
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Thalassemia

Source

Open in PubMed Open full text

Identifiers

PMID: 1990845
PMCID: PMC1683029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1990845-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protection against malaria morbidity: near-fixation of the alpha-thalassemia gene in a Nepalese population.PMID 1990845Read ↗

Molecular analysis of alpha-thalassemia in Nepal: correlation with malaria endemicity.Semantic proximity Read ↗

Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation.Semantic proximity Read ↗

Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development.Semantic proximity Read ↗

Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea.Semantic proximity Read ↗

Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India.Semantic proximity Read ↗

Lack of associations of α(+)-thalassemia with the risk of Plasmodium falciparum and Plasmodium vivax infection and disease in a cohort of children aged 3-21 months from Papua New Guinea.Semantic proximity Read ↗

Thalassaemia and malaria, revisited.Semantic proximity Read ↗

High frequencies of alpha-thalassaemia are the result of natural selection by malaria.Semantic proximity Read ↗

Multiple recombination events are responsible for the heterogeneity of alpha(+)-thalassemia haplotypes among the forest tribes of Andhra Pradesh, India.Semantic proximity Read ↗

Haptoglobin levels are associated with haptoglobin genotype and alpha+ -Thalassemia in a malaria-endemic area.Semantic proximity Read ↗

Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial AnaemiaSemantic proximity Read ↗

Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.