Article
Relationship between NAT1 genotype and phenotype in a Japanese population.
Pharmacogenetics - 1 Apr 2000
Yang M, Katoh T, Delongchamp R, Ozawa S, Kohshi K, Kawamoto T
Abstract excerpt
NAT1, which biotransforms many carcinogens, is genetically polymorphic. This polymorphism has been postulated as a mechanism for susceptibility differences in cancer, possibly due to NAT1 activity differences. However, the relationship between NAT1 genotype and phenotype is not clear. In our study of 110 Japanese, the frequency of the NAT1*10 allele (0.53, 95% confidence interval 0.46-0.59) was higher than others...
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