Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Technical knockout: understanding poxvirus pathogenesis by selectively deleting viral immunomodulatory genes.

Cellular microbiology - 1 Aug 2004

Johnston J B, McFadden Grant

Abstract excerpt

The study of viral pathogens with genomes as large and complex as poxviruses represents a constant experimental challenge. Advances in recombinant DNA technologies have provided sophisticated methods to produce mutants defective in one or more viral genes, termed knockout (KO) viruses, thereby facilitating research into the impact of specific gene products on viral pathogenesis. Such strategies have rapidly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Evolution, Molecular
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Techniques

Share to Molecular Mimicry

Share to Phenotype

Share to Receptors, Virus

Share to Virulence

Source

Identifiers

PMID: 15236637
DOI: 10.1111/j.1462-5822.2004.00423.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Technical knockout: understanding poxvirus pathogenesis by selectively deleting viral immunomodulatory genes.PMID 15236637Read ↗

Evasion of the Innate Immune Type I Interferon System by Monkeypox VirusSemantic proximity Read ↗

Immune Response to Poxvirus Infections in Various AnimalsSemantic proximity Read ↗

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase ActivationSemantic proximity Read ↗

Distinct Roles of Vaccinia Virus NF-κB Inhibitor Proteins A52, B15, and K7 in the Immune ResponseSemantic proximity Read ↗

Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication.Semantic proximity Read ↗

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus InfectionSemantic proximity Read ↗

C7L Family of Poxvirus Host Range Genes Inhibits Antiviral Activities Induced by Type I Interferons and Interferon Regulatory Factor 1Semantic proximity Read ↗

Generation of a complete single-gene knockout bacterial artificial chromosome library of cowpox virus and identification of its essential genes.Semantic proximity Read ↗

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC VectorsSemantic proximity Read ↗

Identification of Poxvirus Genome Uncoating and DNA Replication Factors with Mutually Redundant RolesSemantic proximity Read ↗

Comparative Analysis of Poxvirus Orthologues of the Vaccinia Virus E3 Protein: Modulation of Protein Kinase R Activity, Cytokine Responses, and Virus PathogenicitySemantic proximity Read ↗

What the pox? Review of poxviruses affecting humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.