Article
A minimal conditioning approach to achieve stable multilineage mouse plus rat chimerism.
Transplant immunology - 1 Jun 1995
Abou el-Ezz A Y, Boggs S S, Johnson P C, Li H, Patrene K D, Itskowitz M S, Kaufman C L, Ildstad S T
Abstract excerpt
Transplantation of untreated rat bone marrow into lethally irradiated (950 cGy) mouse recipients results in durable xenogeneic (rat-->mouse) chimerism and confers donor-specific transplantation tolerance for subsequent xenografts. The purpose of the present study was to characterize the minimal d...
Topics
- Animals
- B-Lymphocytes
- Blood Platelets
- Bone Marrow Transplantation
- Dose-Response Relationship, Radiation
- Erythrocytes
- Graft Rejection
- Immune Tolerance
- Killer Cells, Natural
- Male
- Mice
- Mice, Inbred C57BL
- Monocytes
- Phenotype
- Radiation Chimera
- Rats
- Rats, Inbred ACI
- Rats, Inbred F344