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Article

Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice.

Seminars in nephrology - 1 May 2008

Verkman A S

Abstract excerpt

Transgenic mice lacking renal aquaporins (AQPs), or containing mutated AQPs, have been useful in confirming anticipated AQP functions in renal physiology and in discovering new functions. Mice lacking AQPs 1-4 manifest defects in urinary concentrating ability to different extents. Mechanistic studies have confirmed the involvement of AQP1 in near-isosmolar fluid absorption in the proximal tubule, and in...

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Source

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Identifiers

PMID: 18519083
DOI: 10.1016/j.semnephrol.2008.03.004
PMCID: PMC2692584

Genes

AQP1
AQP11
AQP2
AQP3
AQP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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