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Article

Reduced endothelin-3 expression in sporadic Hirschsprung disease.

The British journal of surgery - 1 May 2000

Kenny S E, Hofstra R M, Buys C H, Vaillant C R, Lloyd D A, Edgar D H

Abstract excerpt

BACKGROUND: Enteric aganglionosis in Hirschsprung disease has been linked to genes coding for endothelin-3 (EDN3) and the endothelin B receptor (EDNRB), but there is no such linkage in most patients with sporadic Hirschsprung disease. However, the similarity between the distal colonic aganglionosis in Hirschsprung disease and that due to EDN3 or EDNRB mutations led to the hypothesis that levels of expression of...

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Source

Identifiers

PMID: 10792313
DOI: 10.1046/j.1365-2168.2000.01401.x

Genes

EDN3
EDNRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Reduced endothelin-3 expression in sporadic Hirschsprung disease.PMID 10792313Read ↗

Altered endothelin-3 and endothelin-B receptor mRNA expression in Hirschsprung's disease.Semantic proximity Read ↗

New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease.Semantic proximity Read ↗

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Endothelin-3 Gene Mutations in Isolated and Syndromic Hirschsprung DiseaseSemantic proximity Read ↗

Endothelin-3 gene mutations in isolated and syndromic Hirschsprung disease.Semantic proximity Read ↗

Mutation analysis of the RET, the endothelin-B receptor, and the endothelin-3 genes in sporadic cases of Hirschsprung's disease.Semantic proximity Read ↗

Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease.Semantic proximity Read ↗

[Endothelin B receptor system and Hirschsprung disease].Semantic proximity Read ↗

Mutations of the endothelin-B receptor and endothelin-3 genes in Hirschsprung's disease.Semantic proximity Read ↗

Clinical relationship between EDN-3 gene, EDNRB gene and Hirschsprung's disease.Semantic proximity Read ↗

Analysis of the RET, GDNF, EDN3, and EDNRB genes in patients with intestinal neuronal dysplasia and Hirschsprung disease.Semantic proximity Read ↗

Ednrb−/− mice with hirschsprung disease are missing Gad2-expressing enteric neurons in the ganglionated small intestineSemantic proximity Read ↗

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