Article
Analysis of the RET, GDNF, EDN3, and EDNRB genes in patients with intestinal neuronal dysplasia and Hirschsprung disease.
Gut - 1 May 2001
Gath R, Goessling A, Keller K M, Koletzko S, Coerdt W, Müntefering H, Wirth S, Hofstra R M, Mulligan L, Eng C, von Deimling A
Abstract excerpt
BACKGROUND: Hirschsprung disease (HSCR) is a frequent congenital disorder with an incidence of 1 in 5000 live births, characterised by the absence of parasympathetic intramural ganglion cells in the hindgut resulting in intestinal obstruction in neonates and severe constipation in infants and adults. Intestinal neuronal dysplasia (IND) shares clinical features with HSCR but the submucosal parasympathetic plexus...
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