Article
Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells.
Carcinogenesis - 1 May 2000
Kim D W, Sovak M A, Zanieski G, Nonet G, Romieu-Mourez R, Lau A W, Hafer L J, Yaswen P, Stampfer M, Rogers A E, Russo J, Sonenshein G E
Abstract excerpt
NF-kappaB/Rel is a family of transcription factors which are expressed in all cells; however, in most non-B cells, they are sequestered in the cytoplasm in inactive complexes with specific inhibitory proteins, termed IkappaBs. We have recently shown that NF-kappaB/Rel factors are aberrantly activated in human breast cancer and rodent mammary tumors, and function to promote tumor cell survival and proliferation....
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