A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information.

Abstract excerpt

A general approach to family-based examinations of association between marker alleles and traits is proposed. The approach is based on computing p values by comparing test statistics for association to their conditional distributions given the minimal sufficient statistic under the null hypothesis for the genetic model, sampling plan and population admixture. The approach can be applied with any test statistic,...

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