Article
Genetic evidence for a multi-subunit complex in the O-methyltransferase steps of coenzyme Q biosynthesis.
Biochimica et biophysica acta - 12 Apr 2000
Hsu A Y, Do T Q, Lee P T, Clarke C F
Abstract excerpt
Coq3 O-methyltransferase carries out both O-methylation steps in coenzyme Q (ubiquinone) biosynthesis. The degree to which Coq3 O-methyltransferase activity and expression are dependent on the other seven COQ gene products has been investigated. A panel of yeast mutant strains harboring null mutations in each of the genes required for coenzyme Q biosynthesis (COQ1-COQ8) have been prepared. Mitochondria have been...
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