Article
A peculiar sequence motif in the alpha-1-domain of the HLA-C molecule in psoriasis.
Dermatology (Basel, Switzerland) - 1 Jan 2000
Brazzelli V, Quaglini M, Martinetti M, Nolli G, Salvaneschi L, Cuccia M, Borroni G
Abstract excerpt
BACKGROUND: Most immunogenetic studies restrict the location of the susceptibility gene for psoriasis to the HLA-C locus. OBJECTIVE: The present study evaluates the amino acid sequences of the HLA-C binding groove associated with the disease in a restricted population of Italian descent: Pavia, Northern Italy. METHOD: Forty patients, affected by psoriasis, underwent genomic analysis of exons 2 and 3 of the HLA-C...
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