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Article

RET rearrangements in papillary thyroid carcinomas and adenomas detected by interphase FISH

1 Jan 2000

Abstract excerpt

Activation of the RET protooncogene through somatic rearrangements represents the most common genetic alteration in papillary thyroid carcinoma (PTC). Three main rearranged forms of RET have been described: RET/PTC1 and RET/PTC3, which arise from a paracentric inversion of the long arm of chromosome 10, and RET/PTC2, which originates from a 10;17 translocation. We have developed a dual-color FISH approach to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10773666
DOI: 10.1159/000015485

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