Article
Trisomy 17 as a marker for a subset of noninvasive thyroid nodules with focal features of papillary carcinoma: cytogenetic and molecular analysis of 62 cases and correlation with histological findings.
The Journal of clinical endocrinology and metabolism - 1 Jan 2008
Frau Daniela V, Lai Maria L, Caria Paola, Dettori Tinuccia, Coni Pierpaolo, Faa Gavino, Morandi Luca, Tallini Giovanni, Vanni Roberta
Abstract excerpt
CONTEXT: Differentiated carcinomas of the thyroid are divided into follicular thyroid carcinoma and papillary thyroid carcinoma (PTC), based on their propensity to invade and their cytological features [papillary carcinoma-type nuclear changes (PTC-NCs)]. PTC typically exhibits a diploid karyotype sometimes with inv10(q11.2q21.2), leading to rearranged RET gene. Follicular thyroid carcinomas are often aneuploid...
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