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Article

Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype.

Environmental health perspectives - 1 Dec 2009

Benbrahim-Tallaa Lamia, Tokar Erik J, Diwan Bhalchandra A, Dill Anna L, Coppin Jean-François, Waalkes Michael P

Abstract excerpt

BACKGROUND: Breast cancer has recently been linked to cadmium exposure. Although not uniformly supported, it is hypothesized that cadmium acts as a metalloestrogenic carcinogen via the estrogen receptor (ER). Thus, we studied the effects of chronic exposure to cadmium on the normal human breast epithelial cell line MCF-10A, which is ER-negative but can convert to ER-positive during malignant transformation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20049202
DOI: 10.1289/ehp.0900999
PMCID: PMC2799457

Genes

BRCA1

Provenance

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