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Article

Rapid and specific detection of Helicobacter pylori macrolide resistance in gastric tissue by fluorescent in situ hybridisation.

Gut - 1 May 2000

Trebesius K, Panthel K, Strobel S, Vogt K, Faller G, Kirchner T, Kist M, Heesemann J, Haas R

Abstract excerpt

BACKGROUND: The development of macrolide resistance in Helicobacter pylori is considered an essential reason for failure of antibiotic eradication therapies. The predominant mechanism of resistance to macrolides, particularly clarithromycin, is based on three defined mutations within 23S rRNA, resulting in decreased binding of the antibiotic to the bacterial ribosome. AIM: To develop an rRNA based whole cell...

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Share to Clarithromycin
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to In Situ Hybridization, Fluorescence

Share to Oligonucleotide Probes

Share to RNA, Bacterial

Share to RNA, Ribosomal, 23S

Source

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Identifiers

PMID: 10764702
DOI: 10.1136/gut.46.5.608
PMCID: PMC1727914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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