Article
Direct detection of Helicobacter pylori resistance to macrolides by a polymerase chain reaction/DNA enzyme immunoassay in gastric biopsy specimens.
Gut - 1 Apr 1999
Marais A, Monteiro L, Occhialini A, Pina M, Lamouliatte H, Mégraud F
Abstract excerpt
BACKGROUND: The increasing use of macrolides especially in the treatment of Helicobacter pylori infection has led to an increase in resistant strains. The resistance of H pylori to macrolides, especially clarithromycin, is one of the major causes of eradication failure. In H pylori, clarithromycin resistance is due to point mutations localised in domain V of 23S rRNA. AIM: To develop a molecular technique based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.