Article
Relationship between Expression Levels and Atherogenesis in Scavenger Receptor Class B, Type I Transgenics
1 Jul 2000
Abstract excerpt
Both in vitro and in vivo studies of scavenger receptor class B type I (SR-BI) have implicated it as a likely participant in the metabolism of HDL cholesterol. To investigate the effect of SR-BI on atherogenesis, we examined two lines of SR-BI transgenic mice with high (10-fold increases) and low (2-fold increases) SR-BI expression in an inbred mouse background hemizygous for a human apolipoprotein (apo) B...
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