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Article

Endoribonuclease RegB from bacteriophage T4 is necessary for the degradation of early but not middle or late mRNAs.

Journal of molecular biology - 14 Apr 2000

Sanson B, Hu R M, Troitskayadagger E, Mathy N, Uzan M

Abstract excerpt

The RegB endoribonuclease from bacteriophage T4 cleaves early mRNAs specifically in the middle of the sequence GGAG. We show here that RegB is required for the degradation of bulk T4 early mRNA. In the absence of RegB, the chemical half-life of early transcripts is increased nearly fourfold, whereas their functional half-life is increased twofold. RegB also regulates the translation of several prereplicative...

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Share to Bacteriophage T4
Share to Endoribonucleases
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immediate-Early

Share to Half-Life

Share to Regulatory Sequences, Nucleic Acid

Share to RNA Processing, Post-Transcriptional

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Source

Identifiers

PMID: 10764573
DOI: 10.1006/jmbi.2000.3626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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