Article
The role of the G protein gamma(2) subunit in opioid antinociception in mice.
European journal of pharmacology - 31 Mar 2000
Hosohata K, Logan J K, Varga E, Burkey T H, Vanderah T W, Porreca F, Hruby V J, Roeske W R, Yamamura H I
Abstract excerpt
We examined the role of the gamma(2) subunit of G proteins (Ggamma(2)) in the antinociception produced by c[D-Pen(2), D-Pen(5)]enkephalin (DPDPE) in mice. DPDPE produced 84.0+/-9.0% antinociception in vehicle-treated mice. After intracerebroventricular (i.c.v.) treatment with an antisense phosphorothioate oligodeoxynucleotide to the Ggamma(2) subunit, DPDPE-mediated antinociception decreased to 24.4+/-7.4%. The...
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