Article
Polyglutamine coding genes in bipolar disorder: lack of association with selected candidate loci.
Journal of affective disorders - 1 Apr 2000
Turecki G, Alda M, Grof P, Joober R, Lafrenière R, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, Vojtechovský M, Zvolský P, Nilsson A, Prochazka H, Licht R W, Rasmussen N A, Schou M, Vestergaard P, Holzinger A, Schumann C, Thau K, Rouleau G A
Abstract excerpt
BACKGROUND: Several studies have suggested that expanded trinucleotide repeats, particularly CAG, may have a role in the etiology of BD. Results obtained with the repeat expansion detection technique (RED) have indicated that bipolar patients have an excess of expanded CAG repeats. However, it is not clear which loci account for this difference. METHODS: Using lithium-responsive bipolar patients in order to...
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