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Article

IL-17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts

1 Apr 2000

Abstract excerpt

Human IL-17 is a cytokine secreted by CD4+-activated memory T cells with the profile of effects of a Th1 cytokine. The effects of IL-17 on many cellular constituents of joints suggest that it may participate in inflammatory joint diseases. Proteins of the complement system are known to be regulated by pro- and anti-inflammatory cytokines. The purpose of this work was to study the effect of IL-17 alone and...

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PMID: 10759759
DOI: 10.1046/j.1365-2249.2000.01199.x

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