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Article

RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human.

Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 2000

Moorefield B, Greene E A, Reeder R H

Abstract excerpt

We have cloned a human cDNA that is related to the RNA polymerase I transcription factor Rrn3 of Saccharomyces cerevisiae. The recombinant human protein displays both sequence similarity and immunological crossreactivity to yeast Rrn3 and is capable of rescuing a yeast strain carrying a disruption of the RRN3 gene in vivo. Point mutation of an amino acid that is conserved between the yeast and human proteins...

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Identifiers

PMID: 10758157
DOI: 10.1073/pnas.080063997
PMCID: PMC18300

Genes

RRN3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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