Article
A new method for locating changes in a tree reveals distinct nucleotide polymorphism vs. divergence patterns in mouse mitochondrial control region.
Journal of molecular evolution - 1 Mar 2000
Galtier N, Boursot P
Abstract excerpt
A new, model-based method was devised to locate nucleotide changes in a given phylogenetic tree. For each site, the posterior probability of any possible change in each branch of the tree is computed. This probabilistic method is a valuable alternative to the maximum parsimony method when base composition is skewed (i.e., different from 25% A, 25% C, 25% G, 25% T): computer simulations showed that parsimony...
Topics
- Animals
- DNA, Mitochondrial
- Evolution, Molecular
- Genetic Variation
- Likelihood Functions
- Mice
- Phylogeny
- Polymorphism, Genetic
- Probability
