Article
Allele diversity and germline mutation at the insulin minisatellite.
Human molecular genetics - 22 Mar 2000
Stead J D, Jeffreys A J
Abstract excerpt
Previous analysis of germline mutation at highly unstable GC-rich minisatellites with continuous allele size distributions revealed similar meiotic recombinational mechanisms operating at all loci investigated. The insulin minisatellite has been studied intensively due to its associations with diabetes, polycystic ovary syndrome, obesity and birth size. Its bimodal allele size distribution in Caucasians suggests...
Topics
- Alleles
- Base Sequence
- DNA
- DNA Replication
- Diabetes Mellitus, Type 1
- Genetic Variation
- Germ-Line Mutation
- Insulin
- Minisatellite Repeats
- Molecular Sequence Data
- Polymerase Chain Reaction