Article
Aquaporins as potential drug targets.
Acta pharmacologica Sinica - 1 Apr 2006
Wang Fang, Feng Xue-Chao, Li Yong-Ming, Yang Hong, Ma Tong-Hui
Abstract excerpt
The aquaporins (AQP) are a family of integral membrane proteins that selectively transport water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen mammalian AQP have been molecularly identified and localized to various epithelial, endothelial and other tissues. Phenotype studies of transgenic mouse models of AQP knockout, mutation, and in some cases humans with AQP mutations have...
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