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Article

Characterization of the enzymatic component of Clostridium perfringens iota-toxin.

Journal of bacteriology - 1 Apr 2000

Nagahama M, Sakaguchi Y, Kobayashi K, Ochi S, Sakurai J

Abstract excerpt

The iota(a) component (i(a)) of Clostridium perfringens ADP ribosylates nonmuscle beta/gamma actin and skeletal muscle alpha-actin. Replacement of Arg-295 in i(a) with alanine led to a complete loss of NAD(+)-glycohydrolase (NADase) and ADP-ribosyltransferase (ARTase); that of the residue with lysine caused a drastic reduction in NADase and ARTase activities (<0.1% of the wild-type activities) but did not...

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Identifiers

PMID: 10735850
DOI: 10.1128/JB.182.8.2096-2103.2000
PMCID: PMC111256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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