Article
Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae.
FEBS letters - 24 Mar 2000
Soustre I, Dupuy P H, Silve S, Karst F, Loison G
Abstract excerpt
Certain exogenously-supplied sterols, like ergost-8-enol, are efficiently converted into ergosterol in yeast. We have taken advantage of this property to study the regulation of the Delta8-Delta7-sterol isomerase-encoding ERG2 gene in an ergosterol auxotrophic mutant devoid of squalene-synthase activity. Ergosterol starvation leads to an 8-16-fold increase in ERG2 gene expression. Such an increase was also...
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