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Article

Bcl-2 overexpression sensitizes MCF-7 cells to genistein by multiple mechanisms

1 Oct 2007

Abstract excerpt

Genistein is a soy isoflavone with anti-tumor properties. Genistein-induced apoptosis involves Bcl-2 downregulation. However, overexpression of Bcl-2 in breast cancer has been associated with better prognosis and response to hormonal therapy. To examine genistein's effect on breast cancer cells with different Bcl-2 levels, we established control (MCF-7/PV) and Bcl-2 overexpressing MCF-7 (MCF-7/Bcl-2) cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17786319
DOI: 10.3892/ijo.31.4.867

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