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Article

Evidence for variable selective pressures at MC1R.

American journal of human genetics - 1 Apr 2000

Harding R M, Healy E, Ray A J, Ellis N S, Flanagan N, Todd C, Dixon C, Sajantila A, Jackson I J, Birch-Machin M A, Rees J L

Abstract excerpt

It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date, the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance in human pigmentation. Here we investigate MC1R polymorphism in several populations, for evidence of selection. We conclude that MC1R is under strong functional constraint in Africa, where...

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Identifiers

PMID: 10733465
DOI: 10.1086/302863
PMCID: PMC1288200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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