Article
Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor.
Journal of biochemistry - 1 Mar 2000
Ikuta T, Tachibana T, Watanabe J, Yoshida M, Yoneda Y, Kawajiri K
Abstract excerpt
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that acts in concert with the AhR nuclear translocator (ARNT), and alters gene expression in response to environmental contaminants such as 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD). We have previously shown that AhR contains both a nuclear localization signal (NLS), AhR(13-39), and a nuclear export signal (NES), AhR(55-75), in its...
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