Article
Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15.
Biology of reproduction - 1 Apr 2000
Verma S, Hiby S E, Loke Y W, King A
Abstract excerpt
The natural killer (NK) cells that are present in the uterine mucosa (decidua) during early pregnancy have a distinctive phenotype, CD56(bright) CD16(-). These cells have previously been shown to proliferate and be activated by interleukin (IL)-2. However, IL-2 is absent from the decidua and placenta, and we have therefore investigated whether IL-15 is present in the uterus and can act on decidual NK cells. Both...
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