Article
An IFN regulatory factor-2 DNA-binding domain dominant negative mutant exhibits altered cell growth and gene expression.
Oncogene - 9 Mar 2000
Rubinstein Y R, Driggers P H, Ogryzko V V, Thornton A M, Ozato K, Pontzer C H
Abstract excerpt
In order to study interferon regulatory factor (IRF) family mediation of cell growth regulation, we established U937 cell lines stably transfected with a truncated form of IRF-2 lacking the transcriptional repressor domain. The truncated IRF-2 contained the DNA binding domain (DBD) and bound the ISRE. Phenotypically, the IRF-2 DBD transfectants exhibited reduced cell growth, altered morphology and increased cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.